Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe
نویسندگان
چکیده
Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections.
منابع مشابه
Eighteenth-Century Europe
Chapter 6: Varieties of the Public Sphere To this point, we have encountered changes, as well as continuity, in European politics, economics, society, and thought. Each of these developments contributed to a transformation that some consider the most fundamental transformation of the century -the emergence, between the state sector and private economic sphere, of autonomous institutions of civi...
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